01 - Pat shrimp dry with paper towels and season evenly with kosher salt and black pepper.
02 - Set up three shallow bowls: combine flour, cornstarch, garlic powder, and smoked paprika in the first; beat eggs in the second; place panko breadcrumbs in the third.
03 - Dredge each shrimp in flour mixture, dip into beaten eggs, then press firmly into panko crumbs to coat thoroughly.
04 - Pour 2 inches vegetable oil into deep skillet or Dutch oven and heat to 350°F.
05 - Fry shrimp in batches for 2-3 minutes, turning halfway, until golden brown and crispy. Transfer to paper towel-lined plate to drain.
06 - In small saucepan over low heat, melt butter with honey, hot sauce, and red pepper flakes. Stir until fully combined and heated through.
07 - Toss fried shrimp with hot honey glaze until evenly coated. Serve immediately garnished with fresh chives or parsley and lemon wedges.